Services Drug Development

  • Formulation- and Bio-analyticsPharmaceuticals

  • Pharmacology

    • Pharmacodynamics
      • Primary / secondary pharmacodynamics
      • Vaccination studies
      • Infection studies (safety level L2/S2)  
    • Pharmacokinetics / Toxikokinetics
    • Safety Pharmacology
      • Cardiovascular, respiratory, central nervous and renal system

  • Drug metabolism (DMPK) / ADME

    • DMPK in vitro
      • Metabolism:
        • Metabolic Stability (Liver Microsomes, Hepatocytes)
        • Metabolite Profiling (Liver Microsomes, Hepatocytes)
      • Drug Interaction:
        • CYP Inhibition (Liver Microsomes)
        • CYP Induction (Hepatocytes)
        • CYP Profiling (Supersomes)
        • Plasma Protein Binding
      • Permeability and Transport:
        • CaCo-2 (Permeability & Active Efflux)
        • MDCK (Transport)
      • Adme in vivo (with radio-labelled and non radio-labelled substances)
        • Blood and plasma kinetics
        • Tissue distribution
        • Protein binding

  • Infection studies

  • Skin models / dermal absorption

    • Human skin permeation (semi-static and various animal species)
    • Human skin models (and various animal species)

  • Bioassays

  • Immunoanalytics / Immunogenicity

  • Cellular toxicology

  • Genetic toxicology

    • In vitro test systems
      • Mouse lymphoma assay*
      • HPRT assay
      • Ames test with Salmonella typhimurium and Escherichia coli*
      • Chromosome aberration assay V79 cells or human lymphocytes
      • Micronucleus assay*
      • Comet assay*

        * Screening versions available

    • In vivo test systems
      • Chromosome aberration assay
      • Micronucleus assay
      • DNA-repair: UDS assay
      • Comet assay
    • Photogenotoxicity systems
      • Photo Ames test
      • Photo chromosome aberration assay
      • Photo micronucleus assay

  • General toxicology

    • Single dose toxicity

      different routes of application: e.g. oral, dermal, i.v., i.m., i.p.

    • Repeated dose toxicity

      different routes of application: e.g. oral, dermal, i.v., i.m., i.p.

      • Subacute
      • Subchronic
      • Chronic

  • Immunotoxicology

    • Concomitant to Repeated Dose Toxicity Studies
      • Immune cell phenotyping by flow cytometry
      • Natural killer (NK) cell assays
      • T cell dependent antibody response (TDAR)
      • Serum immunoglobulin isotyping (IgG, IgA, IgM, IgE)
      • Serum cytokine profiling (e.g. Th1/Th2)
      • Serum autoantibodies
      • Customized functional assays

  • Developmental and Reproductive Toxicity (DART)

    • Study of fertility and early embryonic development to implantation
    • Study for effects on Embryo-fetal development
    • Study for effects on pre and post natal development including maternal function
    • Male fertility study
    • Juvenile toxicity Studies

  • Safety pharmacology

    • Cardiovascular system
    • Respiratory system
    • Central nervous system
    • Renal System