ADME and Metabolism
BSL BIOSERVICE offers a full range of in vitro DMPK study formats from simple drug clearance assays over CYP identification to an assessment of CYP induction potential in cultured hepatocytes, supporting all levels of in vitro DMPK profiling for pre-clinical and clinical candidate substances.
DMPK in vitro
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Metabolism
- Metabolic Stability (Liver Microsomes, Hepatocytes)
- Metabolite Profiling (Liver Microsomes, Hepatocytes)
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Drug Interaction
- CYP Inhibition (Liver Microsomes)
- CYP Induction (Hepatocytes)
- CYP Profiling (Supersomes)
- Plasma Protein Binding
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Permeability and Transport
- CaCo-2 (Permeability & Active Efflux)
- MDCK (Transport)
ADME in vivo (with radio-labelled and non radio-labelled substances)
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Blood and plasma kinetics
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Tissue distribution
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Protein binding