Pharmacology

In vitro:

In cooperation with leading research groups BSL BIOSERVICE has established several tests using different tissue culture models to quality control of pharmaceuticals. This offers you the opportunity to investigate a variety of pharmacological aspects at considerably lower costs compared to clinical trials or animal studies. We offer a wide range of services from initial pharmacological screening to functional cellular assays accompanying clinical trials.

In vivo:

Knowledge of pharmacodynamic and pharmacokinetic parameters is essential for the characterisation of active substances. The primary screening of compounds for pharmacological and antimicrobial activities can assist in selecting candidate substances for further development. There is an increasing relevance on generating information on the pharmacokinetic and metabolic behaviour early during the developmental process. We provide a wide range of services to accelerate your candidate development from tailor-made proof-of-concept studies and early assessments of drug metabolism and pharmacokinetics to regulatory IND- enabling safety pharmacology studies.

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  • Dermal absorption

    • Human skin permeation (semi-static and various animal species)
    • Human skin models (and various animal species)

  • Pharmacokinetics / Toxikokinetics

  • Pharmacodynamics

    • Primary / secondary pharmacodynamics
    • Vaccination studies
    • Infection studies (safety level L2/S2)

  • Safety Pharmacology

    • Cardiovascular, respiratory, central nervous and renal system