Toxicology

In vitro:

For years BSL BIOSERVICE has offered a broad scope of in vitro tests, thus establishing a fundamental pool of historical data. Many of our test systems (e.g. genotoxicity tests) meet the basic legislative requirements for the safety testing of new chemicals or drugs. Furthermore, we are well prepared to approach safety evaluation by applying economic screening versions that may help you to estimate the toxicological profile of your substances.

In vivo:

We have a wide range of experience in acute, subchronic and chronic toxicity studies using various routes of administrations in different species. Among repeated dose toxicity studies we offer a comprehensive range of Developmental and Reproductive Toxicity testing (DART) services. All studies are conducted in compliance with Good Laboratory Practices (GLP) for the safety evaluation of Pharmaceuticals, Agrochemicals and Industrial chemicals following OECD, ICH, U.S. EPA testing guidelines.

Comprehensive Toxicology Services

  • Cytotoxicity, Phototoxicity in vitro

  • Single dose toxicity

    • Different routes of application: e.g. oral, dermal, i.v., i.m., i.p.

  • Repeated dose toxicity

    • Different routes of application: e.g. oral, dermal, i.v., i.m., i.p.
      • Subacute
      • Subchronic
      • Chronic

  • Developmental and Reproductive Toxicity (DART)

    • Study of fertility and early embryonic development to implantation
    • Study for effects on Embryo-fetal development
    • Study for effects on pre and post natal development including maternal function
    • Male fertility study
    • Juvenile toxicity Studies

  • Sensitization

    • Delayed Hypersensitization
    • Closed patch according to Buehler
    • Local lymph node assay (LLNA)
    • Photo local lymph node assay
    • Acute systemic anaphylaxis

  • Local tolerance studies (single or repeated applications)

    • Different routes of application:
      • Dermal
      • Ocular
      • Parenteral
      • Intramuscular
      • Intranasal
      • Intravaginal
      • Others (specific tissues)

  • Genetic Toxicology

    • In vitro test systems:
      • Mouse lymphoma assay*
      • HPRT assay
      • Ames test with Salmonella typhimurium and Escherichia coli*
      • Chromosome aberration assay V79 cells or human lymphocytes
      • Micronucleus assay*
      • Comet assay*
      * Screening versions available
    • In vivo test systems:
      • Chromosome aberration assay
      • Micronucleus assay
      • DNA-repair: UDS assay
      • Comet assay
    • Photogenotoxicity systems:
      • Photo Ames test
      • Photo Chromosome aberration assay
      • Photo Micronucleus assay

  • Immunotoxicity

    • Concomitant to Standard Toxicity Studies
      • Immune cell phenotyping by flow cytometry
      • Natural killer (NK) cell assays
      • T cell dependent antibody response (TDAR)
      • Serum immunoglobulin isotyping (IgG, IgA, IgM, IgE)
      • Serum cytokine profiling (e.g. Th1/Th2)
      • Serum autoantibodies
      • Customized functional assays

  • In vitro dermal absorption & toxicology

    • Human skin permeation (semi-static and various animal species)
    • Human skin models (and various animal species)
    • In vitro skin corrosion
    • In vitro phototoxicity with skin models