Pharmacology Testing and Proof of Concept
Pharmacology studies are essential for the identification of undesirable pharmacodynamic properties of a drug candidate that may have relevance to human safety and for the evaluation of adverse pharmacodynamics effects. The specific studies and their design vary based on the individual properties and intended uses of the test substances.
With more than 30 years of experience BSL BIOSERVICE offers a broad spectrum of pharmacology studies in close cooperation with its partners Eurofins BioPharma Product Testing Munich GmbH and Pharmacology Discovery Service. The services range from early pharmacological screening studies in tissue culture, cellular assays accompanying clinical trials as well as a broad based portfolio of in vivo services. We accelerate your candidate development from tailor-made proof of concept studies, like infection and vaccination test designs under bio-safety level 2, pharmacokinetics to IND-enabling safety pharmacology.
in vivo Pharmacology Studies:
Knowledge of pharmacodynamic and pharmacokinetic parameters is essential for the characterization of active substances. The primary screening of compounds for pharmacological activity assists in selecting candidates for further development. There is an increasing emphasis on obtaining information about kinetics and metabolism throughout the early developmental process.
in vitro Pharmacology Studies:
In cooperation with leading research groups, Eurofins BioPharma Product Testing Munich has established several tests using different tissue culture models for quality control of pharmaceuticals. This offers you the opportunity to investigate a variety of pharmacological aspects at considerably lower costs compared to clinical trials or animal studies.
Full Profile Drug Metabolism*
- DMPK in vitro
- ADME in vivo
- Human skin permeation
- Human skin models
Proof of Concept and Efficacy Models*
- Disease Models (oncology, immunology, anti-infective, CNS, gastrointestinal…)
- Humanized mouse models
Pharmacokinetics / Toxicokinetics
- Single / multiple application
- Bioanalytics and biometric evaluation
Safety Pharmacology Core Battery*
- Cardiovascular system (Telemetry)
- Respiratory system (Plethysmography)
- Central nervous system
- Renal system
*partially partnered services